Bolt Biotherapeutics (BOLT.US)

10-Year Study

BOLT.US · Healthcare · Common Stock

About Bolt Biotherapeutics (BOLT.US)

Healthcare

Bolt Biotherapeutics, Inc., a clinical-stage biopharmaceutical company, develops novel immunotherapies for the treatment of cancer. The company's pipeline products include BDC-4182, a next-generation Boltbody ISAC that targets the tumor-associated antigen claudin 18.2 for the treatment of gastric/gastroesophageal junction cancer, pancreatic cancer, and other tumor types; BDC-3042, a dectin-2 agonist antibody program for the treatment of non-small cell lung cancer, melanoma, and other solid tumors; CEA ISAC, a Boltbody ISAC targeting carcinoembryonic antigen cell adhesion molecule 5 for the treatment of solid tumors, including colorectal, non-small cell lung, pancreatic, and breast; and PD-L1 ISAC, a novel human anti-PD-L1 antibody conjugated to a next-generation TLR7/8 agonist payload via a non-cleavable linker to target both tumor and immune cells for the treatment of tumor regression and immunological memory....

Source: EODHD Financial Datasets
Fundamentals updated: Oct 25, 2026

Fundamental Snapshot

Revenue changed -99.7% year-over-year while EPS changed -2.5%. Financially, its return on equity is -111.7%, current ratio stands at 2.61x, debt-to-equity ratio is 1.71x.

Executive Summary: Bolt Biotherapeutics has compounded at -54.3% annually over the last 10 years, with a maximum drawdown of 99.4% and an annualized volatility of 111.7%.

1Y CAGRCAGRCompound Annual Growth Rate — the annualized rate of return over a period, accounting for compounding.Click for full definition →
+28.1%
3Y CAGRCAGRCompound Annual Growth Rate — the annualized rate of return over a period, accounting for compounding.Click for full definition →
-28.7%
5Y CAGRCAGRCompound Annual Growth Rate — the annualized rate of return over a period, accounting for compounding.Click for full definition →
-49.7%
10Y CAGRCAGRCompound Annual Growth Rate — the annualized rate of return over a period, accounting for compounding.Click for full definition →
-54.3%

History & Riski10-year historical performance analysis including CAGR, Max Drawdown, Sharpe & Sortino ratios, annual returns, and rolling volatility — all computed from daily market data.

10-Year Growth of $10,000

View full price history data
DateValue
2021-02-01$10,000
2021-03-01$12,326
2021-04-01$8,375
2021-05-01$6,558
2021-06-01$5,790
2021-07-01$4,176
2021-08-01$6,652
2021-09-01$4,738
2021-10-01$4,903
2021-11-01$3,472
2021-12-01$1,835
2022-01-01$1,438
2022-02-01$1,307
2022-03-01$1,026
2022-04-01$584
2022-05-01$637
2022-06-01$764
2022-07-01$813
2022-08-01$674
2022-09-01$554
2022-10-01$521
2022-11-01$554
2022-12-01$487
2023-01-01$551
2023-02-01$603
2023-03-01$521
2023-04-01$592
2023-05-01$644
2023-06-01$479
2023-07-01$506
2023-08-01$412
2023-09-01$390
2023-10-01$367
2023-11-01$319
2023-12-01$419
2024-01-01$378
2024-02-01$427
2024-03-01$524
2024-04-01$414
2024-05-01$283
2024-06-01$281
2024-07-01$280
2024-08-01$254
2024-09-01$243
2024-10-01$238
2024-11-01$240
2024-12-01$200
2025-01-01$184
2025-02-01$178
2025-03-01$150
2025-04-01$133
2025-05-01$118
2025-06-01$108
2025-07-01$106
2025-08-01$96
2025-09-01$100
2025-10-01$108
2025-11-01$95
2025-12-01$102
2026-01-01$110
2026-02-01$85
2026-03-01$76
2026-04-01$90
2026-05-01$98
2026-06-01$72
2026-07-01$75
2026-08-01$75
2026-09-01$69
2026-10-01$119
Max DrawdownMax DrawdownThe largest peak-to-trough decline in the asset's value over the measurement period.Click for full definition →
99.4%
Sharpe RatioSharpe RatioRisk-adjusted return: how much excess return you earn per unit of total risk (volatility).Click for full definition →
-0.66
Sortino RatioSortino RatioLike Sharpe, but only penalizes downside volatility — a more accurate risk measure for asymmetric return distributions.Click for full definition →
-1.19
Ann. VolatilityAnnualized VolatilityThe annualized standard deviation of an asset's returns — a measure of how much prices fluctuate.Click for full definition →
69.7%
Best YearBest & Worst YearThe single calendar year with the highest and lowest return in the measured period.Click for full definition →
2026 · +16.3%
Worst YearBest & Worst YearThe single calendar year with the highest and lowest return in the measured period.Click for full definition →
2022 · -73.5%
% Positive Years% Positive YearsThe percentage of calendar years in the measurement period where the asset delivered a positive return.Click for full definition →
20%

Annual Returns

View full annual returns data
YearReturn
2022-73.5%
2023-13.8%
2024-52.2%
2025-48.9%
202616.3%

Rolling 12-Month Returns

Rolling 12-Month Annualised Volatility

Historical Drawdowns

Monthly Returns

Monthly Returns Heatmap

YearJanFebMarAprMayJunJulAugSepOctNovDecAnn.
20267.9-23.4-10.618.89.4-26.73.6-0.3-7.572.8——16.3%
2025-8.4-3.2-15.7-11.2-11.5-8.3-2.1-9.23.78.3-12.07.9-48.9%
2024-9.812.922.8-21.1-31.5-0.9-0.1-9.5-4.4-2.10.9-16.5-52.2%
202313.19.5-13.713.78.9-25.65.5-18.5-5.5-5.8-13.031.3-13.8%
2022-21.6-9.1-21.5-43.19.020.06.4-17.1-17.8-6.16.5-12.2-73.5%
2021——23.3-32.1-21.7-11.7-27.959.3-28.83.5-29.2-47.1-81.6%

Risk X-RayiA 19-factor macroeconomic risk decomposition showing exactly which market forces (equity beta, rates, inflation, credit, commodity, crypto) drive this asset's volatility. Powered by multivariate regression against daily factor returns.

Factor Risk Decomposition

Share of annualised volatility attributable to each macro factor.

Total Est. Vol
111.7%
View full factor risk breakdown
FactorRisk Exposure
VTI.US13.6%
VEA.US0.3%
VWO.US-0.3%
QQQ.US-1.6%
VTV.US-0.7%
IJR.US0.8%
QUAL.US-0.6%
SHV.US23.3%
TLT.US-0.4%
LQD.US29.6%
HYG.US0.2%
GLD.US0.2%
USO.US0.1%
VNQ.US-1.2%
BTC-USD.CC1.1%
CPER.US0.2%
VIX.INDX-0.4%
UUP.US0.1%
TIP.US4.5%
Idiosyncratic31.3%

Bolt Biotherapeutics Business Fundamentals

Reported valuation multiples, trailing margins, YoY growth, and balance-sheet liquidity.

Valuation Multiples

Price-to-Sales (P/S)
2.57x
50th pct of 233 Healthcare peers · median 2.58x
Price-to-Book (P/B)
0.25x
6th pct of 236 Healthcare peers · median 2.95x

Profitability & Margins

Gross Margin (TTM)
-357.5%
6th pct of 183 Healthcare peers · median 58.3%
Return on Equity (ROE)
-111.7%
15th pct of 235 Healthcare peers · median -9.4%

Year-over-Year Growth

Revenue Growth (YoY)
-99.7%
2nd pct of 236 Healthcare peers · median +4.0%
EPS Growth (YoY)
-2.5%
34th pct of 200 Healthcare peers · median +14.0%

Financial Position

Debt-to-Equity
1.71x
88th pct of 192 Healthcare peers · median 0.30x
Current Ratio
2.61x
51st pct of 229 Healthcare peers · median 2.50x

Market Sentiment

Short Squeeze RiskLow

Dividend & Income Analysisi10-Year historical income simulation on a $10,000 initial investment, cumulative dividend income generated, average yield on cost, and annual payout table.

Income Simulation

Based on $10,000 initial investment.

Total Income Generated
$0
Avg Yield on Cost
0.00%

Momentum & MacroiPrice momentum indicators: distance from 50/200-Day SMA, 52-Week High proximity, Golden Cross trend signal, RSI momentum gauge, Fibonacci retracement levels, and Beta (market sensitivity).

vs 50-Day SMAMoving Averages (SMA)A rolling average of an asset's price over a defined window — used to identify trends and momentum signals.Click for full definition →
+56.3%
Above/below 50-day moving average
vs 200-Day SMAMoving Averages (SMA)A rolling average of an asset's price over a defined window — used to identify trends and momentum signals.Click for full definition →
+41.1%
Above/below 200-day moving average
vs 52-Week High52-Week HighThe highest price an asset reached in the past 52 weeks — a key reference for momentum and valuation context.Click for full definition →
10.3% from high
Distance from 52-week high
BetaBetaA measure of an asset's sensitivity to broad market movements relative to a benchmark (e.g. S&P 500).Click for full definition →
1.01
Market sensitivity coefficient
Trend SignalGolden Cross & Death CrossTechnical chart patterns that occur when a short-term moving average crosses over a long-term moving average.Click for full definition →
✦ Death Cross
Bearish — 50 SMA below 200 SMA
RSI (14-Day)Relative Strength Index (RSI)A momentum oscillator that measures the speed and change of price movements to identify overbought or oversold conditions.Click for full definition →
75
OversoldNeutralOverbought
Overbought
Fibonacci LevelsFibonacci RetracementTechnical levels based on mathematical ratios that indicate potential support and resistance areas.Click for full definition →
38.2% retracement+13.7%
50.0% retracement+23.9%
61.8% retracement+36.1%
% distance of current price from each 52-week Fibonacci support level.

In-Depth Analysis

BOLT.US — 10-Year Return & Risk Profile

Bolt Biotherapeutics (BOLT.US) has delivered negative annualized growth of 54.3% over the last 10 years. A $10,000 investment at the start of the period would have grown to approximately $4, representing a total return of 100%. Over this period, BOLT.US generated positive annual returns in 2 out of 10 calendar years (20%).

The best single calendar year for BOLT.US was 2026, with a return of +16.3%. The worst year was 2022, when the asset declined 73.5%. This spread between best and worst year is a useful indicator of the range of outcomes an investor might have experienced in a given 12-month window.

The asset's Sharpe ratio of -0.66 is considered poor on a risk-adjusted basis. The Sharpe ratio measures return earned above the risk-free rate per unit of total volatility — a higher reading indicates more efficient return generation relative to the risk taken. Investors focused on risk-adjusted outcomes should weigh this figure alongside absolute CAGR when making allocation decisions.

BOLT.US — Drawdown, Volatility & Downside Risk

BOLT.US's annualized volatility of 69.7% is classified as high relative to the long-run US equity benchmark of approximately 15%. This above-average volatility means investors in BOLT.US have historically experienced larger day-to-day price swings than the broader market, which requires a higher tolerance for short-term portfolio fluctuations.

The asset's maximum peak-to-trough decline over the study period was 99.4% — a catastrophic peak-to-trough decline. Drawdown magnitude is a critical consideration for investors who may need to liquidate positions during market stress, as a larger decline requires proportionally greater subsequent gains to recover to the prior peak. A 99% drawdown, for example, requires a 17786% gain just to break even.

When evaluating BOLT.US for inclusion in a diversified US portfolio, it is important to note that historical volatility and drawdown metrics are backward-looking. They capture the risk environment of the past 10 years, which included the COVID-19 market crash (2020), the 2022 Federal Reserve rate hike cycle, and various geopolitical disruptions. Future risk may differ materially, particularly in response to structural changes in US monetary policy, sector regulation, or macroeconomic regime shifts.

BOLT.US — Macroeconomic Factor Risk Exposure

The macroeconomic factor model attributes 29.6% of BOLT.US's return variance to Investment-Grade Corporate Credit. This means that when Investment-Grade Corporate Credit rises or falls sharply, BOLT.US tends to move in the same direction with meaningful magnitude. Investors who already hold significant exposure to this factor — through other funds or direct equity positions — should be aware of this concentration when sizing their BOLT.US allocation.

The second-largest macro driver is Short-Term Interest Rates, contributing 23.3% of variance. 31.3% of BOLT.US's risk is attributable to idiosyncratic, stock-specific factors that are uncorrelated with the broader macro drivers. A higher idiosyncratic share generally indicates that the fund's performance is more dependent on the security selection or holdings composition of the individual underlying assets, rather than broad market forces.

For US investors building a diversified multi-asset portfolio, understanding BOLT.US's factor exposures helps assess its marginal contribution to overall portfolio risk. Adding BOLT.US alongside assets with low correlation to Investment-Grade Corporate Credit — such as US Treasury bonds, commodities, or assets with significant developed-market ex-US exposure — can reduce the overall portfolio's sensitivity to any single macroeconomic theme.

Compare this AssetiRun a head-to-head backtest and risk analysis against similar assets.

Frequently Asked Questions & Methodology

Is Bolt Biotherapeutics a high-risk investment?

Bolt Biotherapeutics (BOLT.US) has an annualized volatility of 111.7% and experienced a maximum drawdown of 99.4% over the last 10 years. Its primary macro risk driver is LQD.US.

What is the 10-year return of BOLT.US?

Over the past 10 years, BOLT.US has generated a Compound Annual Growth Rate (CAGR) of -54.3%. A $10,000 investment would have grown to approximately $4. It has had a positive return in 20% of calendar years.

What is BOLT.US's Sharpe ratio?

BOLT.US has a Sharpe ratio of -0.66 and a Sortino ratio of -1.19 over the 10-year period. The Sharpe ratio measures risk-adjusted return — how much excess return is earned per unit of volatility. A reading below 1.0 suggests investors were not fully compensated on a risk-adjusted basis.

What is BOLT.US's dividend yield?

BOLT.US does not pay a meaningful dividend. Its returns are driven primarily by price appreciation. Investors seeking regular income may wish to consider dividend-focused alternatives.

Is BOLT.US above its 200-day moving average?

BOLT.US is currently above its 200-day moving average by 41.1%. The current trend signal is: Bearish — 50 SMA below 200 SMA. The 200-day SMA is a widely used long-term trend filter — assets trading above it tend to exhibit positive price momentum.

Data Methodology & Trust

The risk and return information on this page is pre-calculated mathematically using daily market data spanning a 10-year period. Fundamentals (such as P/E Ratio, Market Cap, and Dividend Yield) represent trailing averages and may not immediately reflect real-time live market fluctuations. Advanced scoring models like the Piotroski F-Score and Altman Z-Score are proxies applied to publicly available trailing-twelve-month financial statements and may not account for recent off-balance-sheet events, qualitative company shifts, or sector-specific capital structures. Macroeconomic factor exposures are estimated via multivariate regression against standard market indices. This data is provided for quantitative insight and backtesting research, and should not be misconstrued as tailored financial advice.

Run a Full Backtest on Bolt Biotherapeutics

stresstest.pro lets you simulate DCA vs Lump Sum, Monte Carlo projections, portfolio optimisation, and more — all in seconds.

Start a Free Backtest