aTyr Pharma, Inc.

10-Year Study

ATYR.US · Healthcare · US · Common Stock

Executive Summary: aTyr Pharma, Inc. has compounded at -35.2% annually over the last 10 years, with a maximum drawdown of 99.3% and an annualized volatility of 92.4%.

1Y CAGR
-91.5%
3Y CAGR
-38.2%
5Y CAGR
-36.3%
10Y CAGR
-35.2%

History & Riski10-year historical performance analysis including CAGR, Max Drawdown, Sharpe & Sortino ratios, annual returns, and rolling volatility — all computed from daily market data.

10-Year Growth of $10,000

Max DrawdownMax DrawdownThe largest peak-to-trough decline in the asset's value over the measurement period.Click for full definition →
99.3%
Sharpe RatioSharpe RatioRisk-adjusted return: how much excess return you earn per unit of total risk (volatility).Click for full definition →
-0.19
Sortino RatioSortino RatioLike Sharpe, but only penalizes downside volatility — a more accurate risk measure for asymmetric return distributions.Click for full definition →
-0.31
Ann. VolatilityAnnualized VolatilityThe annualized standard deviation of an asset's returns — a measure of how much prices fluctuate.Click for full definition →
74.7%
Best YearBest & Worst YearThe single calendar year with the highest and lowest return in the measured period.Click for full definition →
2024 · +156.7%
Worst YearBest & Worst YearThe single calendar year with the highest and lowest return in the measured period.Click for full definition →
2018 · -85.8%
% Positive Years% Positive YearsThe percentage of calendar years in the measurement period where the asset delivered a positive return.Click for full definition →
30%

Annual Returns

Rolling 12-Month Returns

Rolling 12-Month Annualised Volatility

Historical Drawdowns

Monthly Returns

Monthly Returns Heatmap

YearJanFebMarAprMayJunJulAugSepOctNovDecAnn.
202612.88.7-18.73.5-34.3———————-32.3%
20256.62.5-23.614.928.813.4-6.914.0-86.620.1-9.80.3-78.4%
202413.120.41.6-19.510.2-9.826.9-5.6-5.977.313.12.5156.7%
20235.0-8.3-0.5-7.116.4-4.8-9.3-13.3-7.1-20.94.08.5-35.6%
2022-23.8-12.87.9-22.2-32.50.724.0-2.6-12.3-17.7-12.61.4-70.7%
2021-5.418.52.3-9.012.17.5-4.518.364.6-5.4-2.9-10.492.5%
202021.6-26.8-24.528.24.218.7-11.0-4.8-14.1-1.937.5-11.0-7.0%
20191.0-4.214.612.9-30.4-15.3-31.5-16.219.03.133.8-13.7-39.9%
20181.4-16.9-10.2-15.1-59.90.8-14.7-7.012.6-25.21.3-19.5-85.8%
201753.521.2-12.5-5.70.03.01.5-11.665.6-5.0-18.8-10.362.8%
2016————-7.0-16.022.7-14.48.9-13.512.7-30.6-39.6%

Risk X-RayiA 19-factor macroeconomic risk decomposition showing exactly which market forces (equity beta, rates, inflation, credit, commodity, crypto) drive this asset's volatility. Powered by multivariate regression against daily factor returns.

Risk Profile Insight: This asset has an estimated annualized volatility of 92.4%. The dominant macroeconomic risk driver is HYG.US, accounting for 12.1% of variance. Idiosyncratic stock-specific factors contribute 71.4%.

10-Year Historical Price Series (Growth of $10,000)
DateSimulated Value
2016-04-0110000
2016-05-019297.752808988764
2016-06-017808.988764044944
2016-07-019578.651685393257
2016-08-018202.247191011236
2016-09-018932.58426966292
2016-10-017724.719101123595
2016-11-018707.865168539325
2016-12-016039.325842696629
2017-01-019269.662921348316
2017-02-0111235.955056179773
2017-03-019831.460674157302
2017-04-019269.662921348316
2017-05-019269.662921348316
2017-06-019550.561797752809
2017-07-019691.011235955055
2017-08-018567.41573033708
2017-09-0114185.393258426966
2017-10-0113483.14606741573
2017-11-0110955.05617977528
2017-12-019831.460674157302
2018-01-019971.91011235955
2018-02-018286.516853932582
2018-03-017443.820224719101
2018-04-016320.224719101123
2018-05-012536.5168539325837
2018-06-012556.179775280899
2018-07-012179.775280898876
2018-08-012028.0898876404494
2018-09-012283.7078651685392
2018-10-011707.8651685393259
2018-11-011730.3370786516853
2018-12-011393.258426966292
2019-01-011407.3033707865168
2019-02-011348.314606741573
2019-03-011544.943820224719
2019-04-011744.38202247191
2019-05-011213.4831460674156
2019-06-011028.0898876404492
2019-07-01704.2536115569823
2019-08-01589.8876404494382
2019-09-01702.2471910112358
2019-10-01724.3178170144461
2019-11-01969.1011235955057
2019-12-01836.6773675762439
2020-01-011017.2552166934189
2020-02-01744.38202247191
2020-03-01561.7977528089887
2020-04-01720.3049759229534
2020-05-01750.4012841091493
2020-06-01890.8507223113965
2020-07-01792.5361155698233
2020-08-01754.414125200642
2020-09-01648.0738362760834
2020-10-01636.0353130016051
2020-11-01874.7993579454254
2020-12-01778.4911717495986
2021-01-01736.3563402889245
2021-02-01872.7929373996789
2021-03-01892.8571428571429
2021-04-01812.6003210272872
2021-05-01910.9149277688603
2021-06-01979.1332263242375
2021-07-01934.991974317817
2021-08-011106.540930979133
2021-09-011821.8298555377205
2021-10-011723.5152487961475
2021-11-011673.3547351524878
2021-12-011498.796147672552
2022-01-011141.653290529695
2022-02-01995.1845906902087
2022-03-011073.4349919743177
2022-04-01834.6709470304976
2022-05-01563.8041733547351
2022-06-01567.817014446228
2022-07-01704.2536115569823
2022-08-01686.1958266452648
2022-09-01601.9261637239165
2022-10-01495.58587479935795
2022-11-01433.3868378812199
2022-12-01439.4060995184591
2023-01-01461.4767255216693
2023-02-01423.35473515248793
2023-03-01421.34831460674155
2023-04-01391.2520064205457
2023-05-01455.4574638844301
2023-06-01433.3868378812199
2023-07-01393.2584269662921
2023-08-01341.091492776886
2023-09-01317.0144462279294
2023-10-01250.80256821829852
2023-11-01260.8346709470305
2023-12-01282.90529695024077
2024-01-01320.02407704654894
2024-02-01385.23274478330654
2024-03-01391.2520064205457
2024-04-01315.008025682183
2024-05-01347.1107544141252
2024-06-01313.0016051364366
2024-07-01397.2712680577849
2024-08-01375.20064205457464
2024-09-01353.13001605136435
2024-10-01626.0032102728732
2024-11-01708.266452648475
2024-12-01726.3242375601926
2025-01-01774.4783306581058
2025-02-01793.5393258426966
2025-03-01605.9390048154092
2025-04-01696.2279293739967
2025-05-01896.8699839486355
2025-06-011017.2552166934189
2025-07-01947.0304975922952
2025-08-011079.4542536115569
2025-09-01144.6629213483146
2025-10-01173.75601926163722
2025-11-01156.7014446227929
2025-12-01157.10272873194222
2026-01-01177.1669341894061
2026-02-01192.61637239165327
2026-03-01156.5008025682183
2026-04-01161.91813804173356
2026-05-01106.38041733547351
Annual Return Matrix
YearAnnual Return
20170.627906976744186
2018-0.8582857142857143
2019-0.39948156682027647
2020-0.0695443645083933
20210.9252577319587629
2022-0.7068273092369478
2023-0.3561643835616438
20241.567375886524823
2025-0.7837016574585636
2026-0.3228607918263091
Total Factor Risk
0.9235504533163604
VTI.US Exposure
-0.021736567331653286
VEA.US Exposure
0.010126919527226738
VWO.US Exposure
0.008690843660181025
QQQ.US Exposure
0.02655346782782891
VTV.US Exposure
-0.007036888398637036
IJR.US Exposure
0.015779397488743675
QUAL.US Exposure
-0.00042192150497143035
SHV.US Exposure
0.0007678907321354863
TLT.US Exposure
-0.0008783519507032279
LQD.US Exposure
0.08558344913088381
HYG.US Exposure
0.12115384730256673
GLD.US Exposure
0.002930922916388467
USO.US Exposure
0.00013812340843718311
VNQ.US Exposure
0.032061328402449976
BTC-USD.CC Exposure
-0.00015485128288214619
CPER.US Exposure
-0.00015962513790257336
VIX.INDX Exposure
0.007114517069675041
UUP.US Exposure
0.005726904023065923
TIP.US Exposure
-0.00020747094784027257
Idiosyncratic Exposure
0.7139680650650071
Value Score
50
Growth Score
50
Profit Score
37.5
Health Score
23.6
Yield Score
0
Moat Score
40

Factor Risk Decomposition

Share of annualised volatility attributable to each macro factor.

Total Est. Vol
92.4%

FundamentalsiCompany financial health metrics: P/E valuation, dividend yield, Piotroski F-Score (9-point profitability signal), Altman Z-Score (bankruptcy risk proxy), and a radar chart across 6 fundamental dimensions. Note: ETFs may show N/A for some metrics.

Fundamental Dimensions

Core Valuation

P/E Ratio (TTM)P/E RatioPrice-to-Earnings ratio — the market price of a stock divided by its earnings per share, a key valuation measure.Click for full definition →N/A
Forward P/EForward P/E RatioA valuation metric that compares the current stock price to estimated future earnings per share.Click for full definition →No estimate availableN/A
Dividend YieldDividend YieldAnnual dividend paid per share divided by the current share price — expressed as a percentage income return.Click for full definition →0.00%
Squeeze RiskShort Squeeze RiskA situation where a sharp rise in the price of a stock forces short sellers to buy shares to cover their positions, further driving up the price.Click for full definition →Low
Market Cap$83.3M
Piotroski F-ScorePiotroski F-ScoreA 9-point scoring system evaluating a company's financial strength across profitability, leverage, and operating efficiency.Click for full definition →
9-point profitability signal
0.0/ 9
Weak
Altman Z-ScoreAltman Z-ScoreA bankruptcy prediction model that combines 5 financial ratios into a single score indicating financial distress risk.Click for full definition →
Bankruptcy risk proxy
1.18
Distress Zone
Income Simulation

Based on $10,000 initial investment.

Total Income Generated
$0
Avg Yield on Cost
0.00%

Momentum & MacroiPrice momentum indicators: distance from 50/200-Day SMA, 52-Week High proximity, Golden Cross trend signal, RSI momentum gauge, Fibonacci retracement levels, and Beta (market sensitivity).

vs 50-Day SMAMoving Averages (SMA)A rolling average of an asset's price over a defined window — used to identify trends and momentum signals.Click for full definition →
-36.7%
Above/below 50-day moving average
vs 200-Day SMAMoving Averages (SMA)A rolling average of an asset's price over a defined window — used to identify trends and momentum signals.Click for full definition →
-66.7%
Above/below 200-day moving average
vs 52-Week High52-Week HighThe highest price an asset reached in the past 52 weeks — a key reference for momentum and valuation context.Click for full definition →
92.0% from high
Distance from 52-week high
BetaBetaA measure of an asset's sensitivity to broad market movements relative to a benchmark (e.g. S&P 500).Click for full definition →
0.56
Market sensitivity coefficient
Trend SignalGolden Cross & Death CrossTechnical chart patterns that occur when a short-term moving average crosses over a long-term moving average.Click for full definition →
✦ Death Cross
Bearish — 50 SMA below 200 SMA
RSI (14-Day)Relative Strength Index (RSI)A momentum oscillator that measures the speed and change of price movements to identify overbought or oversold conditions.Click for full definition →
33
OversoldNeutralOverbought
Neutral
Fibonacci LevelsFibonacci RetracementTechnical levels based on mathematical ratios that indicate potential support and resistance areas.Click for full definition →
38.2% retracement-87.6%
50.0% retracement-85.1%
61.8% retracement-81.4%
% distance of current price from each 52-week Fibonacci support level.

Frequently Asked Questions & Methodology

Is aTyr Pharma, Inc. a high-risk investment?

aTyr Pharma, Inc. (ATYR.US) has an annualized volatility of 92.4% and experienced a maximum drawdown of 99.3% over the last 10 years. Its primary macro risk driver is HYG.US.

What is the 10-year return of ATYR.US?

Over the past 10 years, ATYR.US has generated a Compound Annual Growth Rate (CAGR) of -35.2%. It has had a positive return in 30% of the years measured.

Data Methodology & Trust

The risk and return information on this page is pre-calculated mathematically using daily market data spanning a 10-year period. Fundamentals (such as P/E Ratio, Market Cap, and Dividend Yield) represent trailing averages and may not immediately reflect real-time live market fluctuations. Advanced scoring models like the Piotroski F-Score and Altman Z-Score are proxies applied to publicly available trailing-twelve-month financial statements and may not account for recent off-balance-sheet events, qualitative company shifts, or sector-specific capital structures. Macroeconomic factor exposures are estimated via multivariate regression against standard market indices. This data is provided for quantitative insight and backtesting research, and should not be misconstrued as tailored financial advice.

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